類器官Dexamethasone (DHAP)

簡(jiǎn)要描述：類器官Dexamethasone (DHAP)
類器官（Organoids）是指將成體干細(xì)胞或多能干細(xì)胞在體外三維培養(yǎng)形成的具有一定空間結(jié)構(gòu)的組織類似物。類器官在組織結(jié)構(gòu)、細(xì)胞類型、自我更新能力和功能等方面與來(lái)源組織高度一致，從而在發(fā)育生物學(xué)、疾病造模、精準(zhǔn)醫(yī)學(xué)、藥物研發(fā)、基因和細(xì)胞療法、感染和免疫以及再生醫(yī)學(xué)等生物醫(yī)學(xué)的多個(gè)領(lǐng)域展現(xiàn)出*的優(yōu)勢(shì)。

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類器官Dexamethasone (DHAP)類器官（Organoids）是指將成體干細(xì)胞或多能干細(xì)胞在體外三維培養(yǎng)形成的具有一定空間結(jié)構(gòu)的組織類似物。類器官在組織結(jié)構(gòu)、細(xì)胞類型、自我更新能力和功能等方面與來(lái)源組織高度一致，從而在發(fā)育生物學(xué)、疾病造模、精準(zhǔn)醫(yī)學(xué)、藥物研發(fā)、基因和細(xì)胞療法、感染和免疫以及再生醫(yī)學(xué)等生物醫(yī)學(xué)的多個(gè)領(lǐng)域展現(xiàn)出*的優(yōu)勢(shì)。

產(chǎn)品介紹DESCRIPTION

Background	Dexamethasone is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
Alias	Synonyms,地塞米松,Hexadecadrol,Prednisolone F
M. W t	392.46
Formula	C₂₂H₂₉FO₅
CAS No	50-02-2
Storage	Powder	-20°C	3 years
	In solvent	-80°C	2 years
Solubility	DMSO	250 mg/mL(637.01 mM; ultrasonic and warming and heat to 60°C)
	Ethanol	8.33 mg/mL(21.23 mM; Need ultrasonic)
	H2O	< 0.1 mg/mL(insoluble)

技術(shù)參數(shù)BIOLOGICAL ALTIVITY
In Vitro
Dexamethasone regulates several transcription factors, including activator protein-1, nuclear factor-AT, and nuclear factor-kB, leading to the activation and repression of key genes involved in the inflammatory response^[1].
Dexamethasone potently inhibits granulocyte-macrophage colony stimulating factor (GM-CSF) release from A549 cells with EC50 of 2.2 nM. Dexamethasone (EC50=36 nM) induces transcription of the β2-receptor is found to correlate with glucocorticoid receptor (GR) DNA binding and occurred at 10-100 fold higher concentrations than the inhibition of GM-CSF release. Dexamethasone (IC50=0.5 nM) inhibits a 3×κB (NF-κB, IκBα, and I-κBβ), which is associated with inhibition of GM-CSF release^[2].
In Vivo
It has previously been reported that treatment with Dexamethasone at a dose of 2×5 mg/kg efficiently inhibits lipopolysaccharide (LPS)-induced inflammation. In our experimental system, treatment with a single dose of Dexamethasone 10 mg/kg (i.p.) significantly decreases recruitment of granulocytes as well as spontaneous production of oxygen radicals compared with animals expose to LPS and injected with solvent alone (saline). The effects are statistically significant when administered both 1 h before and 1 h after inhalation of LPS. The number of granulocytes in BALF decreased to levels comparable to healthy animals (given an aerosol of water)^[3].